The middle mouse button (usually the scroll wheel) is surprisingly powerful:
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Open links in a new tab: Middle-click any link
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Close tabs: Middle-click a browser tab
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Auto-scroll: Middle-click anywhere on a scrollable page, then move your mouse to scroll quickly (Windows)
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Pan in Excel or Photoshop: Middle-click and drag
If you’re on a laptop, you can emulate middle-click using touchpad gestures (varies by brand).